2022

Hydraulic permeability and compressive properties of porcine and human synovium Rohanifar, M., Johnston, B.B., Davis, A.L., Guang, Y., Nommensen, K., Fitzpatrick, J.A.J, Pham, C.N., and Setton, L.A. Biophysical Journal

2021

Integrin and syndecan binding peptide-conjugated alginate hydrogel for modulation of nucleus pulposus cell phenotype
Tan, X., Jain, E., Barcellona, M.N., Morris, E., Neal, S., Gupta, M.C., Buchowski, J.M., Kelly, M., Setton, L.A., and Huebsch, N. Biomaterials

Bioactive in situ crosslinkable polymer-peptide hydrogel for cell delivery to the intervertebral disc in a rat model
Barcellona, M.N., Speer, J.E., Jing, L., Patil, D.S., Gupta, M.C., Buchowski, J.M., and Setton, L.A. Acta Biomaterialia

Integrin-mediated interactions with a laminin-presenting substrate modulate biosynthesis and phenotypic expression for cells of the human nucleus pulposus
Speer, J.E., Barcellona, M.N., Jing, L., Liu, B., Lu, M.Y., Kelly, M.P., Buchowski, J.M., Zebala, L.P., Luhmann, S., Gupta, M.C., and Setton, L.A. European Cells & Materials

Size-Dependent Effective Diffusivity in Healthy Human and Porcine Joint Synovium
Guang, Y., Davis, A.L., McGrath, T.M., Pham, C.T.N., Fitzpatrick, J.A.J., and Setton, L.A. Annals of Biomedical Engineering

Electric Field Stimulation for the Functional Assessment of Isolated Dorsal Root Ganglion Neuron Excitability
Berke, I.M., McGrath, T.M., Stivers, J.J., Gui, C., Barcellona, M.N., Gayoso, M.G., Tang, S.Y., Cao, Y.-Q., Gupta, M.C., and Setton, L.A. Annals of Biomedical Engineering

Fund Black scientists
Stevens, K.R., Masters, K.S., Imoukhuede, P.I., Haynes, K.A., Setton, L.A., Cosgriff-Hernandez, E., Lediju Bell, M.A., Rangamani, P., Sakiyama-Elbert, S.E., Finley, S.D., Willits, R.K., Koppes, A.N., Chesler, N.C., Christman, K.L., Allen, J.B., Wong, J.Y., El-Samad, H., Desai, T.A., and Eniola-Adefeso, O. Cell

NF-κB-mediated effects on behavior and cartilage pathology in a non-invasive loading model of post-traumatic osteoarthritis
Berke, I.M., Jain, E., Yavuz, B., McGrath, T., Chen, L., Silva, M.J., Mbalaviele, G., Guilak, F., Kaplan, D.L., and Setton, L.A. Osteoarthritis and Cartilage

Engineered Peptide-Functionalized Hydrogels Modulate the RNA Transcriptome of Human Nucleus Pulposus Cells In Vitro
Barcellona, M.N., Speer, J.E., Jing, L., Gupta, M.C., Buchowski, J.M., Kelly, M.P., and Setton, L.A. bioRxiv

A multiphasic model for determination of water and solute transport across the arterial wall: effects of elastic fiber defects
Guang, Y., Cocciolone, A.J., Crandall, C.L., Johnston, B.B., Setton, L.A., and Wagenseil, J.E. Archive of Applied Mechanics

Development of a library of laminin-mimetic peptide hydrogels for control of nucleus pulposus cell behaviors
Speer, J.E., Barcellona, M.N., Lu, M.Y., Zha, Z., Jing, L., Gupta, M.C., Buchowski, J.M., Kelly, M.P., and Setton, L.A. Journal of Tissue Engineering

Immunoengineering the next generation of arthritis therapies
Klimak, M., Nims, R.J., Pferdehirt, L., Collins, K.H., Harasymowicz, N.S., Oswald, S.J., Setton, L.A., and Guilak, F. Acta Biomaterialia

2020

Control of adhesive ligand density for modulation of nucleus pulposus cell phenotype Barcellona, M.N., Speer, J.E., Fearing, B.V., Jing, L., Pathak, A., Gupta, M.C., Buchowski, J.M., Kelly, M., and Setton, L.A. Biomaterials

Combined Experimental Approach and Finite Element Modeling of Small Molecule Transport through Joint Synovium to Measure Effective Diffusivity
Guang, Y., Mcgrath, T.M., Klug, N.R., Nims, R.J., Shih, C.-C., Bayguinov, P.O., Guilak, F., Pham, C.T.N., Fitzpatrick, J.A.J., and Setton, L.A. Journal of Biomechanical Engineering

Core Competencies for Undergraduates in Bioengineering and Biomedical Engineering: Findings, Consequences, and Recommendations
White, J.A., Gaver, D.P., Butera, R.J., Choi, B., Dunlop, M.J., Grande-Allen, K.J., Grosberg, A., Hitchcock, R.W., Huang-Saad, A.Y., Kotche, M., Kyle, A.M., Lerner, A.L., Linehan, J.H., Linsenmeier, R.A., Miller, M.I., Papin, J.A., Setton, L.A., Sgro, A., Smith, M.L., Zaman, M., and Lee, A.P. Annals of Biomedical Engineering

2019

Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape
Fearing, B.V., Jing, L., Barcellona, M.N., Witte, S.E., Buchowski, J.M., Zebala, L.P., Kelly, M.P., Luhmann, S., Gupta, M.C., Pathak, A., and Setton, L.A. FASEB J.

Behavioral Compensations and Neuronal Remodeling in a Rodent Model of Chronic Intervertebral Disc Degeneration
Leimer, E.M., Gayoso, M.G., Jing, L., Tang, S.Y., Gupta, M.C., and Setton, L.A. Scientific Reports

2018

Amino Acid Profile of Synovial Fluid Following Intra-articular Ankle Fracture
Leimer, E.M., Tanenbaum, L.M., Nettles, D.L., Bell, R.D., Easley, M.E., Setton, L.A., and Adams, S.B. Foot and Ankle International

Intra-articular clearance of labeled dextrans from naive and arthritic rat knee joints Mwangi, T.K., Berke, I.M., Nieves, E.H., Bell, R.D., Adams, S.B., and Setton, L.A. Journal of Controlled Release

Differentiation of human induced pluripotent stem cells into nucleus pulposus-like cells Tang, R., Jing, L., Willard, V.P., Wu, C.-L., Guilak, F., Chen, J., and Setton, L.A. Stem Cell Research and Therapy

2017

CRISPR-Based Epigenome Editing of Cytokine Receptors for the Promotion of Cell Survival and Tissue Deposition in Inflammatory Environments
Farhang, N., Brunger, J.M., Stover, J.D., Thakore, P.I., Lawrence, B., Guilak, F., Gersbach, C.A., Setton, L.A., and Bowles, R.D. Tissue Engineering – Part A

Regulation of human nucleus pulposus cells by peptide-coupled substrates
Bridgen, D.T., Fearing, B.V., Jing, L., Sanchez-Adams, J., Cohan, M.C., Guilak, F., Chen, J., and Setton, L.A. Acta Biomaterialia

Biomaterials for intervertebral disc regeneration and repair
Bowles, R.D., and Setton, L.A. Biomaterials

Inflammatory Microenvironment Persists After Bone Healing in Intra-articular Ankle Fractures
Adams, S.B., Leimer, E.M., Setton, L.A., Bell, R.D., Easley, M.E., Huebner, J.L., Stabler, T.V., Kraus, V.B., Olson, S.A., and Nettles, D.L. Foot and Ankle International

Lipid profile of human synovial fluid following intra-articular ankle fracture
Leimer, E.M., Pappan, K.L., Nettles, D.L., Bell, R.D., Easley, M.E., Olson, S.A., Setton, L.A., and Adams, S.B. Journal of Orthopaedic Research

2016

Identifying molecular phenotype of nucleus pulposus cells in human intervertebral disc with aging and degeneration
Tang, X., Jing, L., Richardson, W.J., Isaacs, R.E., Fitch, R.D., Brown, C.R., Erickson, M.M., Setton, L.A., and Chen, J. Journal of Orthopaedic Research

Advances in combining gene therapy with cell and tissue engineering-based approaches to enhance healing of the meniscus
Cucchiarini, M., McNulty, A.L., Mauck, R.L., Setton, L.A., Guilak, F., and Madry, H. Osteoarthritis and Cartilage

N-cadherin is key to expression of the nucleus pulposus cell phenotype under selective substrate culture conditions
Hwang, P.Y., Jing, L., Chen, J., Lim, F.-L., Tang, R., Choi, H., Cheung, K.M., Risbud, M.V., Gersbach, C.A., Guilak, F., Leung, V.Y., and Setton, L.A. Scientific Reports

In vivo luminescent imaging of NF-κB activity and NF-κB-related serum cytokine levels predict pain sensitivities in a rodent model of peripheral neuropathy
Bowles, R.D., Karikari, I.O., Vanderwerken, D.N., Sinclair, M.S., Bell, R.D., Riebe, K.J., Huebner, J.L., Kraus, V.B., Sempowski, G.D., and Setton, L.A. European Journal of Pain

2015

Synthesis and characterization of silk fibroin microparticles for intra-articular drug delivery Mwangi, T.K., Bowles, R.D., Tainter, D.M., Bell, R.D., Kaplan, D.L., and Setton, L.A. International Journal of Pharmaceutics

N-Cadherin-Mediated Signaling Regulates Cell Phenotype for Nucleus Pulposus Cells of the Intervertebral Disc
Hwang, P.Y., Jing, L., Michael, K.W., Richardson, W.J., Chen, J., and Setton, L.A. Cellular and Molecular Bioengineering

Inflammatory cytokines and matrix metalloproteinases in the synovial fluid after intra-articular ankle fracture
Adams, S.B., Setton, L.A., Bell, R.D., Easley, M.E., Huebner, J.L., Stabler, T., Kraus, V.B., Leimer, E.M., Olson, S.A., and Nettles, D.L. Foot and Ankle International

Sustained intra-articular delivery of IL-1Ra from a thermally-responsive elastin-like polypeptide as a therapy for post-traumatic arthritis
Kimmerling, K.A., Furman, B.D., Mangiapani, D.S., Moverman, M.A., Sinclair, S.M., Huebner, J.L., Chilkoti, A., Kraus, V.B., Setton, L.A., Guilak, F., and Olson, S.A. European Cells and Materials

2014

Photocrosslinkable laminin-functionalized polyethylene glycol hydrogel for intervertebral disc regeneration
Francisco, A.T., Hwang, P.Y., Jeong, C.G., Jing, L., Chen, J., and Setton, L.A. Acta Biomaterialia

The role of extracellular matrix elasticity and composition in regulating the nucleus pulposus cell phenotype in the intervertebral disc: A narrative review
Hwang, P.Y., Chen, J., Jing, L., Hoffman, B.D., and Setton, L.A. Journal of Biomechanical Engineering

Intervertebral disc herniation: Pathophysiology and emerging therapies
Winkelstein, B.A., Allen, K.D., and Setton, L.A. in The Intervertebral Disc.

Molecular characterization of chordoma xenografts generated from a novel primary chordoma cell source and two chordoma cell lines
Karikari, I.O., Gilchrist, C.L., Jing, L., Alcorta, D.A., Chen, J., Richardson, W.J., Gabr, M.A., Bell, R.D., Kelley, M.J., Bagley, C.A., and Setton, L.A. Journal of Neurosurgery: Spine

Screening of hyaluronic acid-poly(ethylene glycol) composite hydrogels to support intervertebral disc cell biosynthesis using artificial neural network analysis
Jeong, C.G., Francisco, A.T., Niu, Z., Mancino, R.L., Craig, S.L., and Setton, L.A. Acta Biomaterialia

In vivo luminescence imaging of nf-kb activity and serum cytokine levels predict pain sensitivities in a rodent model of osteoarthritis
Bowles, R.D., Mata, B.A., Bell, R.D., Mwangi, T.K., Huebner, J.L., Kraus, V.B., and Setton, L.A. Arthritis and Rheumatology

Progress in intra-articular therapy
Evans, C.H., Kraus, V.B., and Setton, L.A. Nature Reviews Rheumatology